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主任 

楊繼江 CHI-CHIANG YANG【110第一學期週課表】

◆ 學　　歷：英國里茲大學(University of Leeds)微生物學系博士

◆ 電　　話：089-318855 分機6900 或 6712

◆ 信　　箱：cyang@nttu.edu.tw

◆ 專　　長：醫學檢驗、病毒學、免疫學、微生物學、細胞凋亡、藥物開發

◆ 開授課程：普通生物學、觀念生物學、生物學實驗、高等免疫學、高等病毒學

重要經歷
  • 國立臺東大學 生物醫學碩士學位學程 學程主任(2021.08-迄今)
  • 國立臺東大學 教授(2017.02-迄今)
  • 中山醫學大學 醫學檢驗暨生物技術學系 教授(2005-2017)
  • 武漢大學醫學院 病毒研究所客座教授暨博士生導師(2002-至今)
  • 英國劍橋大學(University of Cambridge) 醫學研究所訪問教授(2008)
  • 中山醫學大學 傑出校友獎(學術類)(2006)
  • 武漢大學 公共衛生學院名譽教授(2003/10)
  • 美國洛克斐勒大學(Rockefeller University) Aaron Diamond AIDS Research Center訪問學者(1997-1998)

編輯委員(現今擔任下列九份國際期刊之編輯委員)
  • Cellular and Molecular Immunology (SCI, 2016 Impact factor= 5.897)
  • Virus Genes (SCI, 2016 Impact factor= 1.431)
  • The Open Infectious Disease Journal (SJR, Impact factor= 0.200) (2008-present)
  • Oriental Pharmacy and Experimental Medicine (2006-present)
  • World Journal of AIDS (2011-present)
  • World Journal of Virology (2011-present)
  • International Journal of Genuine Traditional Medicine, TANG (KSCI, Impact factor= 0.250) (2011-present)
  • Journal of Tumor (2013-present) 9. Cellular Immunology & Immunotherapeutics (2015-present)

研究著作

◆ 期刊論文：

1. Stevenson AJ, Morrison EE, Chaudhari R, Yang CC, Meredith DM. Processing and intracellular localization of herpes simplex virus type 1 proteinase. J Gen Virol 1997, 78, 671-675.

2. Lin HW, Hsieh YS, Yang YY, Hu CC, Chiou SC, Yang CC*. A novel modified silver staining for detecting protein, DNA and RNA in polyacrylamide gels. J Biomed Lab Sci 1999, 11(4), 122-127.

3. Yang CC*, Lin SJ, Lin KL. A newly identified true late protein of HSV-1 possibly encoded by UL49.5. J Biomed Lab Sci 1999, 11(4), 111-117.

4. Yang CC*, HIV coreceptors and their biological characteristics. Bulletin of Association of Laboratory Medicine, R.O.C. 1999, R.O.C.,Vol. 14, No.2, 46-49.

5. Yang CC*, Brief review of HIV immunology. Bulletin of Association of Laboratory Medicine, R.O.C. 1999, Vol. 14, No.3, 28-33.

6. Yang CC*, The recent advances at ADARC. Bulletin of Association of Laboratory Medicine, R.O.C., 1999, Vol. 14, No.4, 49-50.

7. Yang CC*, Laboratory diagnosis and clinical applications of HIV. Bulletin of Association of Laboratory Medicine, R.O.C. 1999, Vol. 14, N0.4, 53-59.

8. Lin DB, Tsai TP, Yang CC, Wang HM, Nieh WT, Lin UP, Changlai SP, You SL, Ho MS, Chen CJ. Association between seropositivity of antibodies against hepatitis A virus and Helicobacter pylori. Am J Med Trop Hyg 2000; 63 (3, 4): 189-191.

9. Lin DB, Tsai TP, Yang CC, Wang HM, Yuan SC, Cheng MH, You SL, Chen CJ. Current seroprevalence of hepatitis A virus infection among kindergarten children and teachers in Taiwan. Southeast Asian J Trop Med Public Health 2000; 31(1): 25-28.

10. Lee YJ, Liao PH, Chen WK, Yang CC. Preferential cytotoxicity of caffeic acid phenethyl ester analogues on oral cancer cells. Cancer Lett 2000;153:51-56.

11. Tsai CH, Tsai HH, Yang YY, Ku CS, Hu CC, Lin HW, Yang CC*. The in vivo effects of cytokines modulation in Balb/C mice fed with Canavalia ensiformis seeds. J Biomed Lab Sci 2000;12(2): 31-34.

12. Yang CC*, Yang YY, Lin KL, Lin SJ. The different forms of HSV-1 VP22a within purified virion and infected cells. J Microbiol Immunol Infect 2000;33:63-68.

13. Yang CC*, Lin CC, Wang L, Ku CS, Chen CK. Anti-HBc IgG subclasses in different populations by comparing a variety of ELISA plates. J Immunoassay Immunochem 2001;22(1): 33-45.

14. Yang CC*, Ku CS, Lin SJ, Marguerite B, Chen CK. Diagnosis of gastroenteric viruses in fecal specimens from pediatric patients in Taiwan. J Biomed Lab Sci 2001;13(3): 63-71.

15. Tsai CH, Yang CC, Lin SS, Chou MY. The correlation between alteration of p16 gene and clinical status in oral squamous cell carcinoma. J Oral Pathol Med 2001;30:527-531.

16. Hou W, Yang ZC, Yang CC, Zhao M, Liu HY, Chie H, Liu TY, Ding SH. Phylogenetic analyses of hantaan viruses in Hubei, China. China Public Health 2002;18(6):667-669.

17. Hou W, Yang ZQ, Chen KL, Yang CC, Wang WH, Xiao H, Cheng L. Study of emodin against herpes simplex virus in vitro. Chin J Pharm Anal 2003; 23(4):259-262.

18. Huang CR, Yang CC*. Cell death. Bulletin of Association of Laboratory Medicine, R.O.C. 2003, Vol.18. No.2, 1-12.

19. Yang CC*. Virus infection and apoptosis. Bulletin of Association of Laboratory Medicine, R.O.C. 2004, Vol.19. No.5, 13-29.

20. Xu FL, Yang ZQ, Yang CC*, Xiao SY, Xiao H, Wen L. Serological characteristics of a hantavirus from Hubei, China. Acta Virol 2004;48:5-8.

21. Yang YY, Koh LW, Tsai JH, Tsai CH, Wong EFC, Lin SJ, Yang CC*. Involvement of viral and chemical factors with oral cancer in Taiwan. Jpn J Clin Oncol 2004;34:176-183.

22. Yang YY, Koh LW, Tsai JH, Tsai CH, Wong EFC, Lin SJ, Yang CC*. Correlation of viral factors with cervical cancer in Taiwan. J Microbiol Immunol Infect 2004;37(10):282-287.

23. Tsai JH, Luh SP, Yang YY, Koh LW, Wong EFC, Tsai CH , Lin SJ, Yang CC*. Human papilloma virus infection in cervical and oral cancer in Taiwan compared. J Biomed Lab Sci 2004; 16:11-15.

24. Lin SJ, Tsai JH, Tsai CH, Hsu HT, Lin YC, Xu FL, Yang CC*. The in vivo effects of cytokines modulation for balb/c mice fed with a combined chinese herb-soaked solution, Yifei-Ruennhou tea. Immunopharm Immunot 2004;26(3):435-444.

25. Xu FL, Yang ZQ, Cheng L, Yang CC, Liu HY, Xiao H, Wen L, Ding XH, Cheng WK. Selection of differentially expressed signal transduction-associated genes of integrin in hantavirus infected cells. Virol Sinica 2004, 19, 315-319.

26. Lin DB, Lin JB, Chen SH, Yang CC, Chen WK, Chen CJ. Seroepidemiology of hepatitis E virus infection among preschool children in Taiwan. J Med Virol 2004;74:414-418.

27. Tsai JH, Tsai CH, Cheng MH, Lin SJ, Xu FL, Yang CC*. Association of viral factor with non-familial breast cancer in Taiwan by comparison with non-cancerous, fibroadenoma, and thyroid tumor tissues. J Med Virol 2005;75:276-281.

28. Lin SJ, Tsai JH, Tsai CH, Lin YC, Hsu HT, Xu FL, Yang CC*. The in vivo effects of cytokine modulation for Balb/C mice given Canavalia ensiformis (L.) seeds with different heat treatment. Food Chem 2005;91:139-145.

29. Wang L, Lin SJ, Tsai JH, Tsai CH, Tsai CC, Yang CC*. Anti-HBs IgG1 subclass is predominant in individuals who have recovered from HBV infection, chronic carriers and in vaccinees. Med Microbiol Immunol 2005; 194:33-38.

30. Lai HC, Lin SJ, Lin HR, Ku CS, Yang CC*. Phylogenetic analyses of human rotavirus in central Taiwan in 1996, 2001 and 2002. J Clin Virol 2005;32:199-217.

31. Lin SS, Chou MY, Ho CC, Kao CT, Tsai CH, Wang L, Yang CC*. Study of the viral infections and cytokines associated with recurrent aphthous ulceration. Microb Infect 2005;7:635-644.

32. Huang CR, Lin SS, Chou MY, Ho CC, Wang L, Lee YL, Chen CS, Yang CC*. Demonstrating different mode of cell death upon HSV-1 infection in different oral cell populations. Acta Virol 2005;49: 7-15.

33. Ho CC, Lin SS, Chou MY, Chen FL, Hu CC, Chen CS, Lu GY, Yang CC*. Effects of CAPE-like compounds on HIV replication in vitro and modulation of cytokines in vivo. J Antimicrob Chemoth 2005;56: 372-379.

34. Huang TH, Yang CC, Ding SJ, Yen M, Chou MY, Kao CT. Biocompatibility of human osteosarcoma cells to root end filling materials. J Biomed Mater Res 2005;72B(1):140-145.

35. Huang TH, Yang CC, Ding SJ, Yen M, Kao CT, Chou MY. Inflammatory cytokines reaction elicited by root-end filling materials. J Biomed Mater Res 2005;73B(1):123-128.

36. Xu FL, Lee YL, Tsai WY, Lin SJ, Yang ZQ, Yang CC*, Liu HY, Cheng L, Xiao H, Wen L. Effect of cordycepin on hantaan virus 76-118 infection of primary human embryonic pulmonary fibroblasts- characterization of apoptotic effects. Acta Virol 2005;49: 183-193.

37. Chi GCL, Hsu FS, Yang CC, Wei J CC. Scleroderma and failed response to alefacept. Rheumatology 2005, 44;1328-1330.

38. Yang YY, Huang CF, Wei JCC, Ho MS, Wang L, Lin SJ, Tsai WY, Lin CC, Xu FL, Yang CC*. The study of IgG subclass profiles of anti-HBc in populations with different status of HBV infection. Cell Mol Immunol 2005, 2;393-398.

39. Lin SJ, Chen CS, Ho CC, Lin SS, Shih HT, Lee IP, Chou MY, Kao CT, Chen FL, Ho YC, Hsieh KH, Huang CR, Yang CC*. In vitro anti-microbial and in vivo cytokines modulation effects of different prepared Chinese herbal medicines. Food Chem Toxicol. 2006, 44;2078-2085.

40. Tsai TH, Huang CF, Wei JCC, Ho MS, Wang L, Tsai WY, Lin CC, Xu FL, Yang CC*. The study of IgG subclass profiles of anti-HBs in populations with different status of HBV infection. Viral Immunol 2006, 19; 277-284.

41. Huang CF, Lin SS, Ho YC, Chen FL, Yang CC*. The immune response induced by hepatitis B virus principal antigens. Cell Mol Immunol 2006, 3: 97-106.

42. Xu FL, Yang ZQ, Wang L, Lee YL, Yang CC*, Xiao SY, Xiao H, Wen L. Morphological characterization of hantavirus HV114: Hypothesis for morphogenesis. Intervirology 2007, 50; 166-172.

43. Wang L, Tsai TH, Huang CF, Ho MS, Lin DB, Ho YC, Lin SS, Wei JCC, Chou MC, Yang CC*. Utilizing self-prepared ELISA plates for a cross-population study of different anti-HBe IgG subclass profiles. J Med Virol 2007, 79, 495-502.

44. Tsai JH, Hsu CS, Tsai CH, Su JM, Liu YT, Cheng MH, Wei JCC, Chen FL, Yang CC*. Relationship between viral factors, axillary lymph-node status and survival in breast cancer. J Cancer Res Clin Oncol 2007, 133;13-21.

45. Wei JCC, Jan MS, Yu CT, Huang YC, Yang CC, Tsou H, Lee HS, Chou CT, GGT Tsay, Chou MC. Plasma homocysteine status in patients with ankylosing spondylitis. Clin Rheumatol 2007, 26;739-742.

46. Huang CF, Lin SS, Liao PH, Young SC, Yang CC*. The immunopharmaceutical effects and mechanisms of herb medicine. Cell Mol Immunol 2008, 5, 23-31.

47. Tsai HT, Lu TM, Tsai TH, Yang CC*. Immunopathology of hepatitis B virus infection. Int Rev Immunol 2008, 27, 427-446.

48. Lin SS, Xu F, Liao PH, Yang CC*. Recent progress in the development of inhibitors of human imunodeficiency virus (HIV) integrase for the management of HIV infection. Acta Virol 2008, 52, 197-207.

49. Cheng MH, Cheng HT, Lin SS, Young SC, Pai CJ, Liao PH, Chen SC, Chou MY, Yang JJ, Yang CC*. Apoptotic characteristics of MMC-treated HeLa cells and cellular localization and characteristics of induced P-glycoprotein 170. Drug Chem Toxicol 2009, 32. 158-168.

50. Wu JL, Lin YJ, Yang CC, Wu SF, Lin YT, Lin YS, Huang CF. MCRS2 Represses the transactivation activities of Nrf1. BMC Cell Biology 2009, 10: 9.

51. Lu TM, Tsai HT, Cheng YW, Chin LW, Yang CC*. Gastroenteroviruses infection in Taiwan. Open Infect Dis J 2009, 3, 37-43.

52. Lai DS, Chen SC, Chang YH, Chen CY, Lin JB, LinYJ, Yang SF, Yang CC, Chen WK, Lin DB. Pediatric reference intervals for several biochemical analytes in school children in central Taiwan. J Formos Med Assoc 2009, 108, 957-963.

53. Hsu CR, Lu TM, Chin LW, Yang CC*. Possible DNA viral factors of human breast cancer. Cancers 2010, 2(2), 498-512.

54. Hsueh CW, Lin SS, Lin CH, Chien ST, Lin FG, Tsai HT, Huang CF, Yang CC*. Diagnosis and mutation assays of drug resistance related to rifampicin and isoniazid of clinical Mycobacterium tuberculosis isolates in Taiwan. Ann Microbiology 2010, 60, 391-397.

55. Tsai WC, Rao YK, Lin SS, Chou MY, Shen YT, Wu CH, Geethangili M, Yang CC*, Tzeng YM*. Methylantcinate A induces tumor specific growth inhibition in oral cancer cells via Bax-mediated mitochondrial apoptotic pathway. Bioorg Med Chem Lett 2010, 20, 6145-6148.

56. Chin LW, Cheng YW, Lin SS, Lai YY, Lin LY, Chou MY, Chou MC, Yang CC*. Anti-herpes simplex virus effects of berberine from Coptidis rhizome, a major component of a Chinese herbal medicine, Ching-Wei-San. Arch Virol 2010,155(12), 1933-1941.

57. Chou Lin SS, Lu TM, Chao PC, Lai YY, Tsai HT, Chen CS, Lee YP, Chen SJ, Chou MC, Yang CC*. In vivo cytokine modulatory effects of cinnamaldehyde, the major constituent of leaf essential oil from Cinnamomum osmophloeum Kaneh. Phytotherapy Research 2011, 25, 1511-1518.

58. Chou Lin SS, Chin LW, Chao PC, Lai YY, Lin LY, Chou MY, Chou MC, Wei JCC, Yang CC*. In vivo Th1 and Th2 cytokine modulation effects of Rhodiola rosea standarised solution and its major constituent, salidroside. Phytotherapy Research 2011, 25, 1604-1611.

59. Chang HL, Cheng YJ, Su CK, Chen MC, Chang FH, Lin FG, Liu LF, Yuan SSF, Chou MC, Huang CF, Yang CC*. Association of estrogen receptor alpha (ER-alpha) gene Pvull and Xbal polymorphisms with non-small cell lung cancer in Taiwan. Oncol Lett 2012, 3, 462-468.

60. Chen LJ, Tsai HT, Chen WJ, Hsieh CY, Wang PC, Chen CS, L Wang, Yang CC*. In vitro growth of periodontal pathogens inhibited significantly by Lactobacillus fermentum and Lactobacillus salivarius and their fermentative broth. Braz J Microbiol 2012, 1376-1384.

61. Lee YP, Tsai WC, Ko CJ, Rao YK, Yang CR, Chen DR, Yang MH, Yang CC*, Tzeng YM*. Anticancer effects study of eleven triterpenoids derived from Antrodia camphorata. Anticancer Res 2012, 32 (7) 2727-2734.

62. Lee YP, Wang CW, Liao WC, Yang CR, Yeh CT, Tsai CH, Yang CC*, Tzeng YM*. In vitro and in vivo xenograft mice inhibitory effects of Destruxin B on human colorectal cancer. Anticancer Res 2012, 32 (7) 2735-2745.

63. Huang Liu Rosa, Chen SP, Lu TM, Tsai WY, Tsai CH, Yang CC*, Tzeng YM*. Selective apoptotic cell death effects of oral cancer cells treated with destruxin B. BMC Complementary and Alternative Medicine 2014, 14:207.

64. Chen SP, Huang Liu R, Lu TM, Wei JCC, Wu TC, Tsai WY, Tsai CH, Yang CC*. Complementary usage of Rhodiola crenulata (L.) in chronic obstructive pulmonary disease patients: the effects on cytokines and T cells. Phytotherapy Research 2015; 29:518-525.

65. Chen CS, Wang ML, Huang Liu R, Chen SP, Lu TM, Tsai WY, Huang CF, Yang CC*, Tzeng YM* Anti-fatigue effects of Anisomeles indica (L.) Kuntze aqueous extract in mice. Tropical Journal of Pharmaceutical Research 2016, 15(3): 489-495.

66. Yang CC* Viral Immunology: reunion of the conjoined twins disciplines. Cellular & Molecular Immunology 2016, 13:1-2. (Editorial). 67. Huang Liu R, Huang CF, Lu TM, Chen SP, Lu PL, Yang CC* The immunity and therapy of influenza virus infection. Cellular Immunology and Immunotherapeutics. 2016, 1: 1-4.

◆ 專書：

1. 周明勇、楊繼江、楊占秋 (2003)口腔病毒學/藝軒出版社，台北。

2. 楊繼江（2001, 2005）病毒學概論/藝軒出版社，台北。

◆ 專利：

類別

專利名稱

國別

專利號碼

發明人

專利權人

專利核准或申請日

A

用於治療與HIV及HTLV病毒有關病症之組合藥物之化合物及醫藥組合物

中華民國等17國

發明第184922號

楊繼江

楊繼江

92.9.1

A

用於治療與預防癌症之組合藥物

中華民國

發明第190079號

楊繼江、

周明勇、李衍彰、張育超

楊繼江、

周明勇

92.11.11

A

新穎乳酸菌及其用

中華民國

發明第I328034號

楊繼江

楊繼江

99.08.01

A

新穎輪狀病毒之核酸序列及其用途

中華民國

發明第I336625號

楊繼江

楊繼江

100.02.01

A

一種用以預防及/或治療因微生物引起之口腔疾病之醫藥組合

中華民國/中國大陸/香港

發明第I313606號

/ZL200410028679.1/

HK1083199

楊繼江

楊繼江

98.08.21/98.08.12

A

三萜類化合物用於抑制腫瘤之用途

中華民國

發明第I398253號

楊繼江、曾耀銘

楊繼江、

曾耀銘

102.06.11.-

119.03.24

A

改善口腔內細菌群的發酵乳酸桿菌SG-A95（Lactobacillus fermentum SG-A95）及其保健組合物

日本/中華民國/美國/中國大陸

5108068/發明第I383798號/

US8349316B2/

ZL201010174817.2

楊繼江、謝主揚、戴芳雲

生展生物科技股份有限公司

101.10.12/

102.02.01-119.04.26/

102.01.08/102.02.06

A

改善口腔內細菌群的唾液乳酸桿菌及其保健組合物(Lactobacillus salivarius

中國大陸

ZL201010229821.4

楊繼江、謝主揚、魏鈺珊

生展生物科技股份有限公司

103.03.19.

A

薔薇紅景天水性萃取物用於抗流感病毒及免疫調節的用途

中華民國

發明第I419699號

楊繼江

楊繼江

102.12.21

A

魚針草萃取物及其純化物抗流感病毒之用途

中華民國

發明第I453026號

楊繼江、曾耀銘

易宏生物科技有限公司

103.09.21

A

小蘗鹼的用途、黃連水萃物的用途以及包含當歸、生地黃、黃連、牡丹皮及升麻之醫藥組合物的用途

中華民國

發明第I516270號

楊繼江

楊繼江

105/01/11-120/01/25

A

黑殭菌素B的用途

中華民國

發明第I528968號

楊繼江、曾耀銘

楊繼江、

曾耀銘

105/04/11-123/05/55

A

紅景天水性萃取物用於製備改善慢性阻塞性肺病之藥物組合物的用途

中華民國

領證中

楊繼江

楊繼江